Article
Variability of the insulin gene in American blacks with NIDDM. Analysis by single-strand conformational polymorphisms.
Diabetes - 1 Jun 1992
Olansky L, Janssen R, Welling C, Permutt M A
Abstract excerpt
Previous studies of the insulin gene--utilized restriction-fragment--length polymorphisms as markers for potential mutations at this locus. This indirect type of analysis could not define the number of variants that might exist within the structural portions and regulatory regions of the gene in...
Topics
- Base Sequence
- Black People
- Chromosomes, Human, Pair 11
- Cloning, Molecular
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Diabetes Mellitus, Type 2
- Exons
- Genetic Variation
- Humans
- Insulin
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Promoter Regions, Genetic
- United States