Article
BRAF mutation status in gastrointestinal stromal tumors.
American journal of clinical pathology - 1 Jan 2010
Hostein Isabelle, Faur Nicolas, Primois Charlotte, Boury Frédérique, Denard Jérome, Emile Jean-François, Bringuier Pierre-Paul, Scoazec Jean-Yves, Coindre Jean-Michel
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors characterized by mutations of KIT or PDGFRA. The objectives of this study were to evaluate BRAF mutations in GISTs and then to correlate BRAF mutational status in the tumor with clinical parameters, with B-raf expression, and with activation of some cellular pathways. BRAF mutation was screened in 321 GISTs with 70 wild-type GISTs. BRAF V600E was...
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