Article
BRAF gene mutations are rare events in gastroenteropancreatic neuroendocrine tumors.
American journal of clinical pathology - 1 Feb 2005
Tannapfel Andrea, Vomschloss Susanne, Karhoff Dorothee, Markwarth Anett, Hengge Ulrich R, Wittekind Christian, Arnold Rudolf, Hörsch Dieter
Abstract excerpt
The BRAF gene, one of the human isoforms of RAF, is activated by ras, leading to cooperative effects in cells responsive to growth factor signals. We studied the frequency of BRAF and k-ras-2 mutations in primary neuroendocrine gastroenteropancreatic (GEP) tumors. Mutation analysis of the BRAF and k-ras-2 genes was performed in 40 primary neuroendocrine tumors of the GEP system. The expression of extracellular...
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