Article
Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositol-3-Kinase pathway gene alterations in gastrointestinal stromal tumors (GIST).
Cancer letters - 15 Dec 2011
Daniels Marc, Lurkin Irene, Pauli Roland, Erbstösser Erhard, Hildebrandt Uwe, Hellwig Karsten, Zschille Uwe, Lüders Petra, Krüger Gabriele, Knolle Jürgen, Stengel Bernd, Prall Friedrich, Hertel Kay, Lobeck Hartmut, Popp Brigitte, Theissig Franz, Wünsch Peter, Zwarthoff Ellen, Agaimy Abbas, Schneider-Stock Regine
Abstract excerpt
Pathogenetic pathways of gastrointestinal stromal tumors (GIST) lacking mutations in KIT and PDGFRA (∼15%) are still poorly studied. Nearly nothing is known about PI3K alterations in GISTs and only a few GISTs with BRAF mutations have been reported. BRAF mutations (V600E) were found in 3/87 tumors (3.5%) concomitantly were wild type for KIT and PDGFRA. No mutations were detected in KRAS, NRAS, and FGFR3. For the...
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