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Article

FANCC suppresses short telomere-initiated telomere sister chromatid exchange

18 Dec 2009

Abstract excerpt

Telomere shortening has been linked to rare human disorders that present with bone marrow failure including Fanconi anemia (FA). FANCC is one of the most commonly mutated FA genes in FA patients and the FANCC subtype tends to have a relatively early onset of bone marrow failure and hematologic malignancies. Here, we studied the role of Fancc in telomere length regulation in mice. Deletion of Fancc (Fancc(-/-))...

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Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 20022886
DOI: 10.1093/hmg/ddp556

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