Article

Germ cell defects and hematopoietic hypersensitivity to gamma- interferon in mice with a targeted disruption of the Fanconi anemia C gene

1996-07-01

Abstract excerpt

Abstract Fanconi anemia (FA) is an autosomal recessive chromosome instability syndrome characterized by progressive bone marrow (BM) failure, skeletal defects, and increased susceptibility to malignancy. FA cells are hypersensitive to DNA cross-linking agents, oxygen and have cell cycle abnormalities. To develop an animal model of the disease we generated mice homozygous for a targeted deletion of exon 9 of the mu...

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Literature Corpus work: 832e13ed-2eda-5616-8c5a-af97d95cdd86
DOI: 10.1182/blood.v88.1.49.49

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