Article
Receptor-mediated tobacco toxicity: regulation of gene expression through alpha3beta2 nicotinic receptor in oral epithelial cells.
The American journal of pathology - 1 Feb 2005
Arredondo Juan, Chernyavsky Alexander I, Marubio Lisa M, Beaudet Arthur L, Jolkovsky David L, Pinkerton Kent E, Grando Sergei A
Abstract excerpt
Tobacco is a known cause of oral disease but the mechanism remains elusive. Nicotine (Nic) is a likely culprit of pathobiological effects because it displaces the local cytotransmitter acetylcholine from the nicotinic receptors (nAChRs) expressed by oral keratinocytes (KCs). To gain a mechanistic insight into tobacco-induced morbidity in the oral cavity, we studied effects of exposures to environmental tobacco...
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