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Article

Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure.

Nature genetics - 1 May 1999

Miettinen P J, Chin J R, Shum L, Slavkin H C, Shuler C F, Derynck R, Werb Z

Abstract excerpt

Craniofacial malformations are among the most frequent congenital birth defects in humans; cleft palate, that is inadequate fusion of the palatal shelves, occurs with an annual incidence of 1 in 700 to 1 in 1,000 live births among individuals of European descent. The secondary palate arises as bilateral outgrowths from the maxillary processes, and its formation depends on the coordinated development of...

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Source

Identifiers

PMID: 10319864
DOI: 10.1038/8773

Genes

EGFR
TGFA
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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