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Article

Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor.

PloS one - 1 Jan 2008

Kawakita Atsuo, Sato Kazuki, Makino Hatsune, Ikegami Hiroyasu, Takayama Shinichiro, Toyama Yoshiaki, Umezawa Akihiro

Abstract excerpt

BACKGROUND: Cigarette smoking adversely affects endochondral ossification during the course of skeletal growth. Among a plethora of cigarette chemicals, nicotine is one of the primary candidate compounds responsible for the cause of smoking-induced delayed skeletal growth. However, the possible mechanism of delayed skeletal growth caused by nicotine remains unclarified. In the last decade, localization of...

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Identifiers

PMID: 19079602
DOI: 10.1371/journal.pone.0003945
PMCID: PMC2596484

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Source receipt: pubmed, retrieved 7 Sept 2026.

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