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Article

Mechanism of nicotine-induced pulmonary fibroblast transdifferentiation.

American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2005

Rehan Virender K, Wang Ying, Sugano Sharon, Romero Sonia, Chen Xiaoru, Santos Jamie, Khazanchi Aarti, Torday John S

Abstract excerpt

We tested the hypothesis that in vitro nicotine exposure disrupts specific epithelial-mesenchymal paracrine signaling pathways and results in pulmonary interstitial lipofibroblast (LIF)-to-myofibroblast (MYF) transdifferentiation, resulting in altered pulmonary development and function. Studies were done to determine whether nicotine induces LIF-to-MYF transdifferentiation and to elucidate underlying molecular...

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Source

Identifiers

PMID: 15951329
DOI: 10.1152/ajplung.00358.2004

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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