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Article

Transcriptional Profiling Identifies Functional Interactions of TGFβ and PPARβ/δ Signaling

2 Jul 2010

Abstract excerpt

Peroxisome proliferator-activated receptors (PPARs) not only play a key role in regulating metabolic pathways but also modulate inflammatory processes, pointing to a functional interaction between PPAR and cytokine signaling pathways. In this study, we show by genome-wide transcriptional profiling that PPARβ/δ and transforming growth factor-β (TGFβ) pathways functionally interact in human myofibroblasts and that...

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PMID: 20595396
DOI: 10.1074/jbc.m110.142018

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