Article
Identification of an essential gene, l(3)73Ai, with a dominant temperature-sensitive lethal allele, encoding a Drosophila proteasome subunit.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1993
Saville K J, Belote J M
Abstract excerpt
Proteasomes are multicatalytic proteinase complexes that function as a major nonlysosomal proteolytic system in all eukaryotes. These particles are made up of 13-15 nonidentical subunits, and they exhibit multiple endopeptidase activities that promote the intracellular turnover of abnormal polype...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Cysteine Endopeptidases
- Drosophila melanogaster
- Genes, Dominant
- Genes, Insect
- Genes, Lethal
- Macromolecular Substances
- Molecular Sequence Data
- Multienzyme Complexes
- Mutagenesis, Insertional