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Article

Improved somatic mutation profiling in small-cell lung cancer using RNA-sequencing and the T2T-CHM13 genome reference.

Computational biology and chemistry - 1 Apr 2026

Kashyap Pragya, Ahirwar Dinesh Kumar, Yadav Pankaj

Abstract excerpt

Comprehensive identification of somatic mutations (SMs) is essential for understanding the molecular landscape of small cell lung cancer (SCLC). While DNA-sequencing remains a prevalent method for SMs detection, RNA-sequencing (RNA-seq) offers a powerful complementary strategy by focusing on mutations in actively transcribed regions. Despite its potential, the utility of RNA-seq for somatic variant discovery in...

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Identifiers

PMID: 41485300
DOI: 10.1016/j.compbiolchem.2025.108874

Genes

ADGRL1
AKT1
ATN1
COL4A1
FN1
MYC
PTK2
TRAF4
TSC1
UBC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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