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Hepatocyte Growth Factor and Its Receptor Signalling Complex as Targets in Cancer Therapy

1 Jan 2010

Abstract excerpt

Hepatocyte growth factor (HGF) and it's receptor, cMET, have become the focus on intense scrutiny since its discovery in the late 1980s [1 2] as regards it role in cancer. HGF is now known to be a potent morphogen that can regulate tissue and organ regeneration and modulate cell morphology, it is a motogen that can stimulate cell motility and migration, and is a mitogen able to regulate cell growth and death and...

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PMID: 20015008
DOI: 10.2174/1871520611009010002

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