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Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using “click chemistry”

8 Sept 2011

Abstract excerpt

Induction of DNA damage by oxidants such as H(2) O(2) activates the complex network of DNA damage response (DDR) pathways present in cells to initiate DNA repair, halt cell cycle progression, and prepare an apoptotic reaction. We have previously reported that activation of Ataxia Telangiectasia Mutated protein kinase (ATM) and induction of γH2AX are among the early events of the DDR induced by exposure of cells...

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PMID: 21905210
DOI: 10.1002/cyto.a.21137

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