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DNA Damage Recognition via Activated ATM and p53 Pathway in Nonproliferating Human Prostate Tissue

26 Oct 2010

Abstract excerpt

DNA damage response (DDR) pathways have been extensively studied in cancer cell lines and mouse models, but little is known about how DNA damage is recognized by different cell types in nonmalignant, slowly replicating human tissues. Here, we assess, using ex vivo cultures of human prostate tissue, DDR caused by cytotoxic drugs (camptothecin, doxorubicin, etoposide, and cisplatin) and ionizing radiation (IR) in...

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PMID: 20978201
DOI: 10.1158/0008-5472.can-10-0937

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