Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3

11 Apr 2012

Abstract excerpt

In addition to its traditional role in the regulation of calcium homeostasis and bone metabolism, vitamin D also exhibits immunomodulatory, anti-proliferative and cancer preventive activities. Molecular mechanisms that confer the chemo-preventive properties to vitamin D are poorly understood. We previously reported that constitutive phosphorylation of histone H2AX on Ser139 (γH2AX) and activation of ATM (Ser1981...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genomics, phytochemicals, and oxidative stress
Share to Vitamin D Research Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22498490
DOI: 10.18632/aging.100450

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3PMID 22498490Read ↗

A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D.Semantic proximity Read ↗

Kinetics of the UV‐induced DNA damage response in relation to cell cycle phase. Correlation with DNA replicationSemantic proximity Read ↗

Vitamin D Regulation of a SOD1-to-SOD2 Antioxidative Switch to Prevent Osteosarcoma TransformationSemantic proximity Read ↗

Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using “click chemistry”Semantic proximity Read ↗

Vitamin D regulation of a SOD1-to-SOD2 antioxidative switch to prevent osteosarcoma transformationSemantic proximity Read ↗

Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcriptionSemantic proximity Read ↗

Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.Semantic proximity Read ↗

An update on vitamin D signaling and cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.