Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity.

Chirality - 1 Nov 2011

Thacker David L, Modak Anil, Nguyen Phuong D, Flockhart David A, Desta Zeruesenay

Abstract excerpt

AIMS: We have previously shown that the (±)-[(13) C]-pantoprazole breath test is a promising noninvasive probe of CYP2C19 activity. As part of that trial, plasma, breath test indices and CYP2C19 (*2, *3, and *17) genotype were collected. Here, we examined whether [(13) C]-pantoprazole exhibits enantioselective pharmacokinetics and whether this enantioselectivity is correlated with indices of breath test. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 2-Pyridinylmethylsulfinylbenzimidazoles
Share to Breath Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbon Isotopes

Share to Cytochrome P-450 CYP2C19

Share to Enzyme Assays

Share to Stereoisomerism

Share to Substrate Specificity

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 21935988
DOI: 10.1002/chir.21011
PMCID: PMC4409653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity.PMID 21935988Read ↗

Is (+)-[13C]-pantoprazole better than (±)-[13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity?Semantic proximity Read ↗

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test.Semantic proximity Read ↗

Improving CYP2C19 phenotyping using stereoselective omeprazole and 5-hydroxy-omeprazole metabolic ratios.Semantic proximity Read ↗

Stereospecific analysis of omeprazole in human plasma as a probe for CYP2C19 phenotype.Semantic proximity Read ↗

Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children.Semantic proximity Read ↗

PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes.Semantic proximity Read ↗

CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers.Semantic proximity Read ↗

Correlation between R/S enantiomer ratio of lansoprazole and CYP2C19 activity after single oral and enteral administration.Semantic proximity Read ↗

Absorption, distribution, metabolism and excretion of [14C]dexlansoprazole in healthy male subjects.Semantic proximity Read ↗

Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes.Semantic proximity Read ↗

Identification of Escitalopram Metabolic Ratios as Potential Biomarkers for Predicting CYP2C19 Poor Metabolizers.Semantic proximity Read ↗

Increased omeprazole metabolism in carriers of the CYP2C19*17 allele; a pharmacokinetic study in healthy volunteers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.