Article
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.
PloS one - 14 Dec 2009
Sebastiani Paola, Montano Monty, Puca Annibale, Solovieff Nadia, Kojima Toshio, Wang Meng C, Melista Efthymia, Meltzer Micah, Fischer Sylvia E J, Andersen Stacy, Hartley Stephen H, Sedgewick Amanda, Arai Yasumichi, Bergman Aviv, Barzilai Nir, Terry Dellara F, Riva Alberto, Anselmi Chiara Viviani, Malovini Alberto, Kitamoto Aya, Sawabe Motoji, Arai Tomio, Gondo Yasuyuki, Steinberg Martin H, Hirose Nobuyoshi, Atzmon Gil, Ruvkun Gary, Baldwin Clinton T, Perls Thomas T
Abstract excerpt
BACKGROUND: The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered. METHODOLOGY/PRINCIPAL FINDINGS: Here, we first show that 18...
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