Article
Role of HIF-1alpha in proton-mediated CXCR4 down-regulation in endothelial cells.
Cardiovascular research - 1 May 2010
Melchionna Roberta, Romani Marta, Ambrosino Valeria, D'Arcangelo Daniela, Cencioni Chiara, Porcelli Daniele, Toietta Gabriele, Truffa Silvia, Gaetano Carlo, Mangoni Antonella, Pozzoli Ombretta, Cappuzzello Claudia, Capogrossi Maurizio C, Napolitano Monica
Abstract excerpt
AIMS: Acidification is associated with a variety of pathological and physiological conditions. In the present study, we aimed at investigating whether acidic pH may regulate endothelial cell (EC) functions via the chemokine receptor CXCR4, a key modulator of EC biological activities. METHODS AND RESULTS: Exposure of ECs to acidic pH reversibly inhibited mRNA and protein CXCR4 expression, CXCL12/stromal...
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