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Article

Aging Influences the Metabolic and Inflammatory Phenotype in an Experimental Mouse Model of Acute Lung Injury.

The journals of gerontology. Series A, Biological sciences and medical sciences - 30 Apr 2021

Gibbs Kevin W, Chuang Key Chia-Chi, Belfield Lanazha, Krall Jennifer, Purcell Lina, Liu Chun, Files D Clark

Abstract excerpt

Increased age is a risk factor for poor outcomes from respiratory failure and acute respiratory distress syndrome (ARDS). In this study, we sought to define age-related differences in lung inflammation, muscle injury, and metabolism after intratracheal lipopolysaccharide (IT-LPS) acute lung injury (ALI) in adult (6 months) and aged (18-20 months) male C57BL/6 mice. We also investigated age-related changes in...

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Identifiers

PMID: 32997738
DOI: 10.1093/gerona/glaa248
PMCID: PMC8087268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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