Article
Methionine sulfoxide reductase B (MsrB) of Mycobacterium smegmatis plays a limited role in resisting oxidative stress.
Tuberculosis (Edinburgh, Scotland) - 1 Dec 2009
Dhandayuthapani Subramanian, Jagannath Chinnaswamy, Nino Celina, Saikolappan Sankaralingam, Sasindran Smitha J
Abstract excerpt
Pathogenic mycobacteria including Mycobacterium tuberculosis resists phagocyte generated reactive oxygen intermediates (ROI) and this constitutes an important virulence mechanism. We have previously reported, using Mycobacterium smegmatis as a model to identify the bacterial components that resist intracellular ROI, that an antioxidant methionine sulfoxide reductase A (MsrA) plays a critical role in this process....
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