Article
Methionine sulfoxide reductases are essential for virulence of Salmonella typhimurium.
PloS one - 1 Jan 2011
Denkel Luisa A, Horst Sarah A, Rouf Syed Fazle, Kitowski Vera, Böhm Oliver M, Rhen Mikael, Jäger Timo, Bange Franz-Christoph
Abstract excerpt
Production of reactive oxygen species represents a fundamental innate defense against microbes in a diversity of host organisms. Oxidative stress, amongst others, converts peptidyl and free methionine to a mixture of methionine-S- (Met-S-SO) and methionine-R-sulfoxides (Met-R-SO). To cope with such oxidative damage, methionine sulfoxide reductases MsrA and MsrB are known to reduce MetSOs, the former being...
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