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Article

Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol.

Antimicrobial agents and chemotherapy - 1 Sept 2007

Miller Christopher C, Rawat Mamta, Johnson Todd, Av-Gay Yossef

Abstract excerpt

Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.

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Identifiers

PMID: 17638697
DOI: 10.1128/AAC.00347-07
PMCID: PMC2043170

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