Article
Significance of four methionine sulfoxide reductases in Staphylococcus aureus.
PloS one - 1 Jan 2015
Singh Vineet K, Vaish Manisha, Johansson Trintje R, Baum Kyle R, Ring Robert P, Singh Saumya, Shukla Sanjay K, Moskovitz Jackob
Abstract excerpt
Staphylococcus aureus is a major human pathogen and emergence of antibiotic resistance in clinical staphylococcal isolates raises concerns about our ability to control these infections. Cell wall-active antibiotics cause elevated synthesis of methionine sulfoxide reductases (Msrs: MsrA1 and MsrB) in S. aureus. MsrA and MsrB enzymes reduce S-epimers and R-epimers of methionine sulfoxide, respectively, that are...
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