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Article

Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.

Human molecular genetics - 15 Mar 2012

Zhou Xiaobo, Baron Rebecca M, Hardin Megan, Cho Michael H, Zielinski Jan, Hawrylkiewicz Iwona, Sliwinski Pawel, Hersh Craig P, Mancini John D, Lu Ke, Thibault Derek, Donahue Amy L, Klanderman Barbara J, Rosner Bernard, Raby Benjamin A, Lu Quan, Geldart Adriana M, Layne Matthew D, Perrella Mark A, Weiss Scott T, Choi Augustine M K, Silverman Edwin K

Abstract excerpt

Multiple intergenic single-nucleotide polymorphisms (SNPs) near hedgehog interacting protein (HHIP) on chromosome 4q31 have been strongly associated with pulmonary function levels and moderate-to-severe chronic obstructive pulmonary disease (COPD). However, whether the effects of variants in this region are related to HHIP or another gene has not been proven. We confirmed genetic association of SNPs in the 4q31...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Electrophoretic Mobility Shift Assay

Share to Enhancer Elements, Genetic

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Source

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Identifiers

PMID: 22140090
DOI: 10.1093/hmg/ddr569
PMCID: PMC3284120

Genes

HHIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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