Article
Lipophilic cations: a group of model substrates for the multidrug-resistance transporter.
Biochemistry - 25 Feb 1992
Gros P, Talbot F, Tang-Wai D, Bibi E, Kaback H R
Abstract excerpt
The possibility that simple lipophilic cations such as tetraphenylphosphonium (TPA+), triphenylmethylphosphonium (TPMP+), and diphenyldimethylphosphonium (DDP+) are substrates for the multidrug-resistance transport protein, P-glycoprotein, was tested. Hamster cells transfected with and overexpressing mouse mdr1 or mouse mdr3 exhibit high levels of resistance to TPP+ and TPA+ (20-fold) and somewhat lower levels of...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenosine Triphosphate
- Animals
- Arsenicals
- CHO Cells
- Cations
- Cell Survival
- Cricetinae
- Electrophoresis, Polyacrylamide Gel
- Gramicidin
- Membrane Glycoproteins