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Article

Lipophilic cations: a group of model substrates for the multidrug-resistance transporter.

Biochemistry - 25 Feb 1992

Gros P, Talbot F, Tang-Wai D, Bibi E, Kaback H R

Abstract excerpt

The possibility that simple lipophilic cations such as tetraphenylphosphonium (TPA+), triphenylmethylphosphonium (TPMP+), and diphenyldimethylphosphonium (DDP+) are substrates for the multidrug-resistance transport protein, P-glycoprotein, was tested. Hamster cells transfected with and overexpressing mouse mdr1 or mouse mdr3 exhibit high levels of resistance to TPP+ and TPA+ (20-fold) and somewhat lower levels of...

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Identifiers

PMID: 1371401
DOI: 10.1021/bi00122a014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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