Article
Biochemical and genetic characterization of the multidrug resistance phenotype in murine macrophage-like J774.2 cells.
Biochemical pharmacology - 9 Jan 1992
Kirschner L S, Greenberger L M, Hsu S I, Yang C P, Cohen D, Piekarz R L, Castillo G, Han E K, Yu L J, Horwitz S B
Abstract excerpt
The development of multidrug resistance (MDR) in malignant tumors is a major obstacle to the treatment of many cancers. MDR sublines have been derived from the J774.2 mouse macrophage-like cell line and utilized to characterize the phenotype at the biochemical and genetic level. Two isoforms of t...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Affinity Labels
- Animals
- Cell Line
- DNA
- Drug Resistance
- Gene Expression
- Macrophages
- Membrane Glycoproteins
- Mice
- Phenotype