Article
Biochemical and genetic characterization of the multidrug resistance phenotype in murine macrophage-like J774.2 cells.
Biochemical pharmacology - 9 Jan 1992
Kirschner L S, Greenberger L M, Hsu S I, Yang C P, Cohen D, Piekarz R L, Castillo G, Han E K, Yu L J, Horwitz S B
Abstract excerpt
The development of multidrug resistance (MDR) in malignant tumors is a major obstacle to the treatment of many cancers. MDR sublines have been derived from the J774.2 mouse macrophage-like cell line and utilized to characterize the phenotype at the biochemical and genetic level. Two isoforms of the drug resistance-associated P-glycoprotein are present and distinguishable both electrophoretically and...
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