Article
Pentose phosphate pathway alterations in multi-drug resistant leukemic T-cells: 31P NMR and enzymatic studies.
Anticancer research - 1 Jan 2000
Ferretti A, Chen L L, Di Vito M, Barca S, Tombesi M, Cianfriglia M, Bozzi A, Strom R, Podo F
Abstract excerpt
31P NMR studies were carried out on the parental drug-sensitive human T-lymphoblastoid cell line CCRI-CEM (CEM) and its multi-drug-resistant (MDR) CEM-VBL100 variants, to assess the role of the pentose phosphate (PP) in MDR expression. CEM and CEM-VBL100 were incubated in the presence of 2-deoxyglucose, as recently proposed by our group (Clin. Chim. Acta 208: 39, 1992). Accumulation of 2-deoxyglucose 6-phosphate...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Blotting, Northern
- Carrier Proteins
- Dactinomycin
- Doxorubicin
- Drug Resistance
- Genetic Variation
- Glucose-6-Phosphate
- Glucosephosphates
- Humans