Article
Parental imprinting of the mouse insulin-like growth factor II gene.
Cell - 22 Feb 1991
DeChiara T M, Robertson E J, Efstratiadis A
Abstract excerpt
We are studying mice that carry a targeted disruption of the gene encoding insulin-like growth factor II (IGF-II). Transmission of this mutation through the male germline results in heterozygous progeny that are growth deficient. In contrast, when the disrupted gene is transmitted maternally, the heterozygous offspring are phenotypically normal. Therefore, the difference in growth phenotypes depends on the type...
Topics
- Animals
- Chimera
- Crosses, Genetic
- Female
- Genes
- Genetic Carrier Screening
- Insulin-Like Growth Factor II
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred Strains