Article
SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations.
Blood - 4 Feb 2010
Nowak Daniel, Ogawa Seishi, Müschen Markus, Kato Motohiro, Kawamata Norihiko, Meixel Antonie, Nowak Verena, Kim Han S, Kang Sharon, Paquette Ronald, Chang Mi-Sook, Thoennissen Nils H, Thoenissen Nils H, Mossner Max, Hofmann Wolf-Karsten, Kohlmann Alexander, Weiss Tamara, Haferlach Torsten, Haferlach Claudia, Koeffler H Phillip
Abstract excerpt
To elucidate whether tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia is associated with characteristic genomic alterations, we analyzed DNA samples from 45 TKI-resistant chronic myeloid leukemia patients with 250K single nucleotide polymorphism arrays. From 20 patients, matched serial samples of pretreatment and TKI resistance time points were available. Eleven of the 45 TKI-resistant...
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