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Article

SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations.

Blood - 4 Feb 2010

Nowak Daniel, Ogawa Seishi, Müschen Markus, Kato Motohiro, Kawamata Norihiko, Meixel Antonie, Nowak Verena, Kim Han S, Kang Sharon, Paquette Ronald, Chang Mi-Sook, Thoennissen Nils H, Thoenissen Nils H, Mossner Max, Hofmann Wolf-Karsten, Kohlmann Alexander, Weiss Tamara, Haferlach Torsten, Haferlach Claudia, Koeffler H Phillip

Abstract excerpt

To elucidate whether tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia is associated with characteristic genomic alterations, we analyzed DNA samples from 45 TKI-resistant chronic myeloid leukemia patients with 250K single nucleotide polymorphism arrays. From 20 patients, mat...

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Identifiers

PMID: 19965645
DOI: 10.1182/blood-2009-03-210377
PMCID: PMC2817631

Genes

ABL1
BCR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19965645-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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