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Epigenetic Profiling in Chronic Lymphocytic Leukemia Reveals Novel Methylation Targets

1 Apr 2004

Abstract excerpt

CpG island methylation is an epigenetic alteration that contributes to tumorigenesis by transcriptional inactivation of genes. Little is known about the overall levels of CpG island methylation in chronic lymphocytic leukemia (CLL). To provide a baseline estimate of global aberrant methylation and identify target sequences for additional investigation, we performed Restriction Landmark Genomic Scanning on 10 CLL...

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PMID: 15059895
DOI: 10.1158/0008-5472.can-03-2870

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