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Article

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

30 Mar 2013

Abstract excerpt

Genomic instability is a hallmark of chronic myeloid leukemia in chronic phase (CML-CP) resulting in BCR-ABL1 mutations encoding resistance to tyrosine kinase inhibitors (TKIs) and/or additional chromosomal aberrations leading to disease relapse and/or malignant progression. TKI-naive and TKI-treated leukemia stem cells (LSCs) and leukemia progenitor cells (LPCs) accumulate high levels of reactive oxygen species...

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Identifiers

PMID: 23543457
DOI: 10.1182/blood-2012-11-466938

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