Article
High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors.
Haematologica - 1 Sept 2010
Marincevic Millaray, Cahill Nicola, Gunnarsson Rebeqa, Isaksson Anders, Mansouri Mahmoud, Göransson Hanna, Rasmussen Markus, Jansson Mattias, Ryan Fergus, Karlsson Karin, Adami Hans-Olov, Davi Fred, Jurlander Jesper, Juliusson Gunnar, Stamatopoulos Kostas, Rosenquist Richard
Abstract excerpt
BACKGROUND: The existence of multiple subsets of chronic lymphocytic leukemia expressing 'stereotyped' B-cell receptors implies the involvement of antigen(s) in leukemogenesis. Studies also indicate that 'stereotypy' may influence the clinical course of patients with chronic lymphocytic leukemia, for example, in subsets with stereotyped IGHV3-21 and IGHV4-34 B-cell receptors; however, little is known regarding...
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