Article
Expression of human hormone-sensitive lipase in white adipose tissue of transgenic mice increases lipase activity but does not enhance in vitro lipolysis.
Journal of lipid research - 1 Jan 2003
Lucas Stéphanie, Tavernier Geneviève, Tiraby Claire, Mairal Aline, Langin Dominique
Abstract excerpt
Hormone-sensitive lipase (HSL) catalyzes the hydrolysis of acylglycerols and cholesteryl esters (CEs). The enzyme is highly expressed in adipose tissues (ATs), where it is thought to play an important role in fat mobilization. The purpose of the present work was to study the effect of a physiological increase of HSL expression in vivo. Transgenic mice were produced with a 21 kb human genomic fragment encompassing...
Topics
- Adipose Tissue
- Animals
- Body Composition
- Diet
- Dietary Fats
- Female
- Gene Expression
- Humans
- Hydrolases
- Lipase
- Lipid Metabolism
- Lipolysis
- Male
- Mice
- Mice, Transgenic
- Pedigree
- Phenotype
- RNA, Messenger