HLA-DPB1 0501 is associated with susceptibility to anti-aquaporin-4 antibodies positive neuromyelitis optica in southern Han Chinese.

doi:10.1016/j.jneuroim.2010.11.004

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Article

HLA-DPB1 0501 is associated with susceptibility to anti-aquaporin-4 antibodies positive neuromyelitis optica in southern Han Chinese.

Journal of neuroimmunology - 1 Apr 2011

Wang Honghao, Dai Yongqiang, Qiu Wei, Zhong Xiaonan, Wu Aimin, Wang Yuge, Lu Zhengqi, Bao Jian, Hu Xueqiang

Abstract excerpt

OBJECTIVES: To analyze the role of HLA-DRB1 and -DPB1 alleles in the pathogenesis of neuromyelitis optica (NMO) and multiple sclerosis in Southern Han Chinese. METHODS: Thirty serum anti-aquaporin 4 antibodies (AQP4-Ab)-positive NMO patients, 53 conventional multiple sclerosis (C-MS) patients, and 93 controls (CTLs) were enrolled. The HLA-DRB1 and -DPB1 alleles of the subjects were determined by sequencing-based...

Topics

Adult
Aquaporin 4
Asian People
Autoantibodies
Base Sequence
China
Female
Genetic Predisposition to Disease
HLA-DP Antigens
HLA-DP beta-Chains
Humans
Male
Neuromyelitis Optica

Source

Open in PubMed

Identifiers

PMID: 21130504
DOI: 10.1016/j.jneuroim.2010.11.004

Genes

AQP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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