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Article

Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2010

Marjanovic Olivera, Miyata Toshiko, Goodridge Amador, Kendall Lon V, Riley Lee W

Abstract excerpt

Mycobacterium tuberculosis genome contains four related sets of an operon called mce (mce1-4). The disruption of one of these operons, mce1, causes M. tuberculosis to become hypervirulent, whereas the mce3 and mce4 operon mutants are attenuated in mice. This study examined the phenotype of the mce2 operon mutant. The deletion of mce2 operon in M. tuberculosis H37Rv had no effect on bacterial growth in 7H9 liquid...

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Identifiers

PMID: 19963438
DOI: 10.1016/j.tube.2009.10.004
PMCID: PMC3228843

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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