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Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro.

Infection and immunity - 1 May 2005

Downing Katrina J, Mischenko Vladimir V, Shleeva Margarita O, Young Danielle I, Young Michael, Kaprelyants Arseny S, Apt Alexander S, Mizrahi Valerie

Abstract excerpt

Mycobacterium tuberculosis contains five genes, rpfA through rpfE, that bear significant homology to the resuscitation-promoting factor (rpf) gene of Micrococcus luteus, whose product is required to resuscitate the growth of dormant cultures of M. luteus and is essential for the growth of this organism. Previous studies have shown that deletion of any one of the five rpf-like genes did not affect the growth or...

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Identifiers

PMID: 15845511
DOI: 10.1128/IAI.73.5.3038-3043.2005
PMCID: PMC1087353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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