Article
Posttreatment reactivation of tuberculosis in mice caused by Mycobacterium tuberculosis disrupted in mce1R.
The Journal of infectious diseases - 1 Sept 2010
Cheigh Chan-Ick, Senaratne Ryan, Uchida Yujiro, Casali Nicola, Kendall Lon V, Riley Lee W
Abstract excerpt
BACKGROUND: The reactivation of tuberculosis arises in persons who are latently infected and in those who have been previously treated. The mechanism of the reactivation of tuberculosis in either situation is not well understood. A 13-gene mce1 operon of Mycobacterium tuberculosis was previously shown to be associated with latent infection in mice and may also play a role in reactivation. METHODS: We tested mce1...
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