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Study of the role of Mce3R on the transcription of mce genes of Mycobacterium tuberculosis

27 Feb 2008

Abstract excerpt

BACKGROUND: mce3 is one of the four virulence-related mce operons of Mycobacterium tuberculosis. In a previous work we showed that the overexpression of Mce3R in Mycobacterium smegmatis and M. tuberculosis abolishes the expression of lacZ fused to the mce3 promoter, indicating that Mce3R represses mce3 transcription. RESULTS: We obtained a knockout mutant strain of M. tuberculosis H37Rv by inserting a hygromycin...

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PMID: 18304349
DOI: 10.1186/1471-2180-8-38

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