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Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice

17 Jan 2008

Abstract excerpt

The Mycobacterium tuberculosis genome contains four copies of an operon called mce (mce1-4). Previously we reported that M. tuberculosis disrupted in the mce1 operon is more virulent than wild-type M. tuberculosis in mice. We generated single deletion mutants in mce3 (Deltamce3) and mce4 (Deltamce4) operons and a double deletion mutant (Deltamce3/4). Similar doubling times and growth characteristics were observed...

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PMID: 18201981
DOI: 10.1099/jmm.0.47454-0

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