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Article

Comparative metabolic profiling of mce1 operon mutant vs wild-type Mycobacterium tuberculosis strains.

Pathogens and disease - 1 Nov 2015

Queiroz Adriano, Medina-Cleghorn Daniel, Marjanovic Olivera, Nomura Daniel K, Riley Lee W

Abstract excerpt

Mycobacterium tuberculosis disrupted in a 13-gene operon (mce1) accumulates free mycolic acids (FM) in its cell wall and causes accelerated death in mice. Here, to more comprehensively analyze differences in their cell wall lipid composition, we used an untargeted metabolomics approach to compare the lipid profiles of wild-type and mce1 operon mutant strains. By liquid chromatography-mass spectrometry, we...

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Identifiers

PMID: 26319139
DOI: 10.1093/femspd/ftv066
PMCID: PMC4626588

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Source receipt: pubmed, retrieved 7 Sept 2026.

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