Article
Mutation in mce operons attenuates Mycobacterium tuberculosis virulence.
Microbes and infection - 1 Mar 2005
Gioffré Andrea, Infante Eduardo, Aguilar Diana, Santangelo María De la Paz, Klepp Laura, Amadio Ariel, Meikle Virginia, Etchechoury Ignacio, Romano María Isabel, Cataldi Angel, Hernández Rogelio Pando, Bigi Fabiana
Abstract excerpt
On the Mycobacterium tuberculosis genome there are four mce operons, all of which are similar in sequence and organization, and code for putatively exported proteins. To investigate whether Mce proteins are essential for virulence, we generated knock-out mutants in mce1, mce2 and mce3 operons of M. tuberculosis and evaluated their ability to multiply in a mammalian host. The allelic replacement was confirmed in...
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