Article
The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-beta1.
Clinical immunology (Orlando, Fla.) - 1 Mar 2010
Paladino Natalia, Flores Ana Claudia, Fainboim Hugo, Schroder Teresa, Cuarterolo Miriam, Lezama Carol, Ballerga Esteban Gonzáles, Levi Diana, Tanno Hugo, Costanzo Gabriel, Arruvito Lourdes, Fainboim Leonardo
Abstract excerpt
We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-beta1 genetic polymorphisms in the different outcome of PAH and AAH. We found a significant increase of "high producer" 25GG genotype in PAH and 10CC in AAH. Low inflammation and low fibrosis in AAH was...
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