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Article

Different gender-associated genotype risks of Wegener's granulomatosis and microscopic polyangiitis.

Clinical immunology (Orlando, Fla.) - 1 Dec 2003

Bártfai Zoltán, Gaede Karoline I, Russell Kimberly A, Muraközy Gabriella, Müller-Quernheim Joachim, Specks Ulrich

Abstract excerpt

Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) are systemic small vessel vasculitides associated with ANCA (AAV). Predominant Th1 and Th2 cytokine patterns have been reported for WG and MPA, respectively. Consequently, genotypes suppressing Th1 responses or augmenting Th2 responses may be more frequent in MPA than in WG. Transforming growth beta1 (TGF-beta1) and interleukin-10 (IL-10) genes may...

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PMID: 14697748
DOI: 10.1016/s1521-6616(03)00211-0

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