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Article

Mechanisms of I(Ks) suppression in LQT1 mutants.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2000

Bianchi L, Priori S G, Napolitano C, Surewicz K A, Dennis A T, Memmi M, Schwartz P J, Brown A M

Abstract excerpt

Mutations in the cardiac potassium ion channel gene KCNQ1 (voltage-gated K(+) channel subtype KvLQT1) cause LQT1, the most common type of hereditary long Q-T syndrome. KvLQT1 mutations prolong Q-T by reducing the repolarizing cardiac current [slow delayed rectifier K(+) current (I(Ks) )], but, fo...

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Source

Identifiers

PMID: 11087258
DOI: 10.1152/ajpheart.2000.279.6.H3003

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11087258-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Mechanisms of I(Ks) suppression in LQT1 mutants.PMID 11087258Read ↗

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