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Article

Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.

PloS one - 24 Nov 2009

Brusko Todd M, Wasserfall Clive H, Hulme Maigan A, Cabrera Roniel, Schatz Desmond, Atkinson Mark A

Abstract excerpt

BACKGROUND: CD25, a component of the IL-2 receptor, is important in T cell proliferation, activation induced cell death, as well as the actions of both regulatory (Treg) and effector (Teff) T cells. Recent genome wide association studies have implicated the CD25 locus as an important region for genetic susceptibility to a number of autoimmune disorders, with serum levels of soluble CD25 receptor (sCD25) serving...

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PMID: 19956753
DOI: 10.1371/journal.pone.0007980
PMCID: PMC2775921

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