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Article

Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus.

Arthritis and rheumatism - 1 Jul 2008

Venigalla Ram Kumar Chowdary, Tretter Theresa, Krienke Stefan, Max Regina, Eckstein Volker, Blank Norbert, Fiehn Christoph, Ho Anthony Dick, Lorenz Hanns-Martin

Abstract excerpt

OBJECTIVE: CD4+,CD25high regulatory T (Treg) cells play a crucial role in the maintenance of self tolerance and prevention of organ-specific autoimmunity. The presence of many in vivo-preactivated CD4+,CD25++ T cells in patients with systemic lupus erythematosus (SLE) poses a difficulty in discriminating CD25++ activated T cells from CD25high Treg cells. To overcome this problem, we analyzed the phenotype and...

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PMID: 18576316
DOI: 10.1002/art.23556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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