Article
Detection of FOXL2 C134W Mutation Status by a Novel BaseScope In Situ Hybridization Assay is Highly Sensitive and Specific for Adult Granulosa Cell Tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2023
Hammer Phoebe M, Wang Aihui, Beard Crystal, Zdravkovic Sabrina, Tenney Troy, Liang Brooke, Das Ishani, Bremer Ryan, Wang Li-Chong, McCluggage W Glenn, Stewart Colin J R, Howitt Brooke E
Abstract excerpt
Adult granulosa cell tumors (AGCTs) are a molecularly distinct group of malignant ovarian sex cord-stromal tumors (SCSTs) characterized by a nearly ubiquitous c.402C>G/p.C134W mutation in FOXL2 (hereafter referred to as "C134W"). In some cases, AGCT exhibits marked morphologic overlap with other SCSTs and has an identical immunophenotype, and molecular testing may be necessary to help confirm the diagnosis....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.