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Article

Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.

PloS one - 30 Nov 2009

Malakhova Margarita, Kurinov Igor, Liu Kangdong, Zheng Duo, D'Angelo Igor, Shim Jung-Hyun, Steinman Valerie, Bode Ann M, Dong Zigang

Abstract excerpt

The p90 ribosomal protein kinase 2 (RSK2) is a highly expressed Ser/Thr kinase activated by growth factors and is involved in cancer cell proliferation and tumor promoter-induced cell transformation. RSK2 possesses two non-identical kinase domains, and the structure of its N-terminal domain (NTD), which is responsible for phosphorylation of a variety of substrates, is unknown. The crystal structure of the NTD...

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Identifiers

PMID: 19956600
DOI: 10.1371/journal.pone.0008044
PMCID: PMC2779450

Genes

PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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